Cancer Terms

ADAM11 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Metalloproteinase -> ADAM11 Protein

ADAM11 Protein Definition

Encoded by human ADAM11 Gene (ADAM Family, Peptidase M12b Family), the 769-amino acid 83 kD (precursor) type I membrane ADAM11 Protein (isoforms MDC-769 and MDC-524) is implicated in cell-cell/-matrix interactions of muscle development, neurogenesis, and fertilization. Membrane-anchored ADAM zinc metalloproteases contain disintegrin domains related to snake venom disintegrins. A putative integrin ligand, ADAM11 is a metalloprotease-like noncatalytic protein predominantly expressed in brain that contains an EGF-like domain and a conserved disintegrin domain AVN(E/D)CD motif. The precursor may be cleaved by a furin endopeptidase. ADAM11 disruptions occur in breast and ovarian cancers. (from LocusLink, Swiss-Prot, OMIM, and NCI)

ADAM11 Protein Synonyms

ADAM11 Protein, A Disintegrin and Metalloproteinase Domain 11 Protein, ADAM11, Metalloproteinase-Like, Disintegrin-Like and Cysteine-Rich Protein

Terms in ADAM11 Protein category



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