ADAMTS1 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Metalloproteinase -> ADAMTS1 Protein

ADAMTS1 Protein Definition

A disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS-1), encoded by the ADAMTS1 gene is a member of the ADAMTS protein family. It cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. It has anti-angiogenic activity and inhibits endothelial cell proliferation. ADAMTS1 may be associated with various inflammatory processes as well as development of cancer cachexia. It is likely to be necessary for normal growth, fertility, and organ morphology and function. ADAMTS1 is secreted and associated with the extracellular matrix. The Spacer Domain and the TSP Type-1 Domains are important for a tight interaction with the extracellular matrix. ADAMTS1 is expressed as a 110-kD protein, an 85-kD protein after cleavage at the subtilisin site, or as a 67-kD protein, which is most abundant, generated by an additional processing event. (From LocusLink, Swiss_Prot and NCI)

ADAMTS1 Protein Synonyms

A Disintegrin and Metalloprotease with Thrombospondin Motifs-1, A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1, ADAM-TS1, ADAMTS1, METH-1

ADAMTS1 Protein

ADAMTS1 Protein Definition

ADAMTS1 Protein Synonyms

Terms in ADAMTS1 Protein category