Cancer Terms

AF-17 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Factor -> AF-17 Protein

AF-17 Protein Definition

Encoded by human MLLT6 Gene, 1093-aa 112-kDa AF-17 Protein has high similarity to AF10 and contains amino acid stretches associated with transcriptional repression or activation: a 3-prime leucine-zipper dimerization motif and a terminal cysteine-rich domain of 3 zinc fingers (2 PHD-type) similar to a domain in Br140 protein. A common acute leukemia chromosomal translocation t(11;17)(q23;q21) involves fusion of MLL/HRX and MLLT6 that produces a rogue activator protein.

AF-17 Protein Synonyms

AF-17 Protein, AF17, MLLT6, Trithorax Homolog 6

Terms in AF-17 Protein category



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