AF-17 Protein
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AF-17 Protein Definition
Encoded by human MLLT6 Gene, 1093-aa 112-kDa AF-17 Protein has high similarity to AF10 and contains amino acid stretches associated with transcriptional repression or activation: a 3-prime leucine-zipper dimerization motif and a terminal cysteine-rich domain of 3 zinc fingers (2 PHD-type) similar to a domain in Br140 protein. A common acute leukemia chromosomal translocation t(11;17)(q23;q21) involves fusion of MLL/HRX and MLLT6 that produces a rogue activator protein.
AF-17 Protein Synonyms
AF-17 Protein, AF17, MLLT6, Trithorax Homolog 6
Terms in AF-17 Protein category
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