AF-4 Protein
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AF-4 Protein Definition
Widely expressed by human MLLT2 Gene (AF4 Family), 1210-aa 131-kDa AF-4 Protein is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus and high sequence homology with ENL protein. A common acute leukemia chromosomal translocation t(4;11)(q21;q23) involves a fusion of MLLT2 and MLL/HRX that form reciprocal products coding for chimeric rogue proteins.
AF-4 Protein Synonyms
AF-4 Protein, AF4, FEL Protein, MLLT2, Proto-Oncogene AF4, Trithorax Homolog 2
Terms in AF-4 Protein category
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