AF-9 Protein
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AF-9 Protein Definition
Encoded by human MLLT3 Gene, 568-aa 63-kDa AF-9 Protein is a putative transcription factor similar to TFG3/ANC1 (Yeast) and contains similar functional domains as MLLT1 and MLLT2 (Human), including nuclear targeting sequences, serine-rich and proline-rich regions, and stretches abundant in basic amino acids. A common acute leukemia chromosomal translocation t(9;11)(p22;q23) involves a fusion of MLLT3 and MLL/HRX that produces a chimeric rogue activator protein.
AF-9 Protein Synonyms
AF-9 Protein, AF9, MLLT3, Trithorax Homolog 3
Terms in AF-9 Protein category
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