APAF1 wt Allele

Cancer Terms -> Gene -> Apoptosis Regulation Gene -> Apoptosis Promoter Gene -> APAF1 Gene -> APAF1 wt Allele

APAF1 wt Allele Definition

Human APAF1 wild-type allele is located in the vicinity of 9q22.32 and is approximately 90 kb in length. This allele, which encodes apoptotic protease-activating factor 1, plays a role in the mediation of caspase cleavage and the propagation of apoptosis. APAF1 allele is inactivated in metastatic melanomas, leading to defects in the execution of apoptotic cell death and chemoresistance.

APAF1 wt Allele Synonyms

APAF1 wt Allele, Apoptotic Protease Activating Factor 1 wt Allele, KIAA0413

Terms in APAF1 wt Allele category

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