AT Hook Motif
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HMG Domain -> AT Hook Motif
AT Hook Motif Definition
Highly conserved peptide motifs of the HMG-I(Y) proteins that preferentially bind, in vivo and in vitro, to the narrow minor groove of stretches of AT-rich DNA. The AT Hook Motif tethers and unbends the minor groove of the DNA with very little specificity for the DNA sequence. The AT hook motif has a narrow DNA recognize surface which is devoid of hydrophobic amino acids and does not significantly distort the B-form DNA structure.
AT Hook Motif Synonyms
AT Hook Motif, AT Hook Domain, ATH
Terms in AT Hook Motif category
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