Cancer Terms

ATN-161

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Angiogenesis Inhibitor -> Endothelial-Specific Integrin-Survival Signaling Inhibitor -> Alpha V Beta Inhibitor -> ATN-161

ATN-161 Definition

A small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. This receptor blockade may result in inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, angiogenesis, and tumor progression. Integrin alpha5beta1 is expressed on endothelial cells and plays a crucial role in endothelial cell adhesion and migration.

ATN-161 Synonyms

ATN-161

Terms in ATN-161 category



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