AU-RNA Binding Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> RNA Binding Protein -> AU-RNA Binding Protein

AU-RNA Binding Protein Definition

AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. (LocusLink)

AU-RNA Binding Protein Synonyms

AU RNA Binding Protein, 3-Methylglutaconyl-CoA Hydratase, AU RNA-Binding Protein, AU RNA-Binding Protein/enoyl-Coenzyme A Hydratase, AU-Specific RNA Binding Protein, AUH, Enoyl-Coenzyme A Hydratase, MGA Type I

Terms in AU-RNA Binding Protein category

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