Activated-p21cdc42Hs Kinase
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Activated-p21cdc42Hs Kinase Definition
Activated p21cdc42Hs Kinase, encoded by the ACK1 gene, is a non-receptor tyrosine kinase. It binds CDC42 in its GTP-bound activated form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The encoded protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of CDC42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. (From LocusLink, OMIM and NCI)
Activated-p21cdc42Hs Kinase Synonyms
Activated p21cdc42Hs Kinase, ACK1, Activated CDC42 kinase 1
Terms in Activated-p21cdc42Hs Kinase category
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