Activin A Receptor Type-I

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Serine-Threonine Kinase -> Activin A Receptor Type-I

Activin A Receptor Type-I Definition

Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases that include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Encoded by human ACVR1 Gene, Activin A Receptor Type I signals a particular transcriptional response in concert with activin type II receptors. (LocusLink)

Activin A Receptor Type-I Synonyms

Activin A Receptor, Type I, ACVR1, Activin A Receptor, Type II-Like Kinase 2, EC 2.7.1.37, Hydroxyalkyl-Protein Kinase

Activin A Receptor Type-I

Activin A Receptor Type-I Definition

Activin A Receptor Type-I Synonyms

Terms in Activin A Receptor Type-I category