Activin-A Receptor Type-II-Like-1 Protein
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Activin-A Receptor Type-II-Like-1 Protein Definition
Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The ACVRL1 gene encodes a protein that shares similar domain structures with 3 other closely related ALK proteins (ALK2, ALK3, and ALK4) that together form a subfamily of receptor serine/threonine kinases. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2) also known as Rendu-Osler-Weber syndrome 2 (ORW2).
Activin-A Receptor Type-II-Like-1 Protein Synonyms
Activin A Receptor Type II-Like 1, ACVRL1, ACVRLK1, Activin A Receptor, Type II-Like Kinase, Activin Receptor-like Kinase 1, EC 2.7.1.37, Serine/threonine-protein kinase Receptor R3 Precursor, TGF-B Superfamily Receptor Type I
Terms in Activin-A Receptor Type-II-Like-1 Protein category
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