Cancer Terms

Activin-A Type-B Receptor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Serine-Threonine Kinase -> Activin-A Type-B Receptor

Activin-A Type-B Receptor Definition

Expressed in kidney, pancreas, brain, lung, and liver and encoded by human ACVR1B Gene (TGFBR Family), 505-aa 57-kD Activin A Type IB Receptor (isoforms A, B, and C) is a type I membrane protein with intracellular Ser/Thr kinase domain. Isoform A contains a complete kinase domain; B and C have truncated kinase domains and distinct C-termini. Activins signal through a transmembrane heteromeric complex of type I and type II receptors that all contain a ligand-binding extracellular domain with a cysteine-rich region. Type I receptors are essential for signaling and type II receptors are required for binding ligand. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.

Activin-A Type-B Receptor Synonyms

Activin A Type IB Receptor, ACTR-IB, ALK-4, Activin A Receptor, Type II-Like Kinase 4, Activin Receptor-Like Kinase 4, SKR2, Serine/Threonine-Protein Kinase Receptor R2

Terms in Activin-A Type-B Receptor category



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