Activin-A Type-II Receptor

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Activin-A Type-II Receptor Definition

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Activin A type II receptor, encoded by the ACVR2 gene, is a receptor for activin A, activin B, and activin C and constitutively active kinase. Type I receptors are essential for transmembrane signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. (From LocusLink, OMIM and NCI)

Activin-A Type-II Receptor Synonyms

Activin A Type II Receptor, ACTR-II, ACTRIIA, ACVR2

Terms in Activin-A Type-II Receptor category

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