Activin-A Type-IIB Receptor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Serine-Threonine Kinase -> Activin-A Type-IIB Receptor

Activin-A Type-IIB Receptor Definition

Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A type IIB receptor, encoded by the ACVR2 gene and a receptor for activin A, activin B, and activin C, displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink, Swiss_Prot)

Activin-A Type-IIB Receptor Synonyms

Activin A Type IIB Receptor, ACTR-IIB, ACVR2B

Terms in Activin-A Type-IIB Receptor category

---

Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.