Acyclovir
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Nucleic Acid Synthesis Inhibitor -> Acyclovir
Acyclovir Definition
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV. (NCI04)
Acyclovir Synonyms
Acyclovir, 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one, 9-[(2-Hydroxyethoxy)-methyl]guanine, 9-[(2-Hydroxyethoxy)methyl]guanine, ACV, ACYCLOVIR, Acicloftal, Aclovir, Acycloguanosine, BW-248U, Cargosil, Virorax, Wellcome-248U, Zovirax, acyclovir
Terms in Acyclovir category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.