Cancer Terms

Adenine Nucleotide Translocator-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Transport Protein -> Adenosine Nucleotide Transporter -> Adenine Nucleotide Translocator-1

Adenine Nucleotide Translocator-1 Definition

Expressed in heart, kidney, liver, skeletal muscle by human SLC25A4 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric Adenine Nucleotide Translocator-1 is an integral membrane protein embedded asymmetrically in the inner mitochondrial membrane that catalyzes transmembrane exchange of ADP and ATP and determines the rate of ADP/ATP flux between mitochondrion and cytosol. Strongly similar to murine Ant1, ANT1 contains 3 solute carrier (Solcar) repeats and the signature RRRMMM motif of nucleotide carriers; six alpha helices form a compact transmembrane domain. Defects in SLC25A4 are a cause of PEO.

Adenine Nucleotide Translocator-1 Synonyms

Adenine Nucleotide Translocator-1, ADP-ATP Translocase-1, ANT, ANT1, Heart-Skeletal Muscle ADP-ATP Carrier Protein-T1, Mitochondrial Adenine Nucleotide Translocator Solute Carrier Family 25 Member-4, Skeletal Muscle Adenine Nucleotide Translocator-1, T1

Terms in Adenine Nucleotide Translocator-1 category



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