Adenovirus Encoding Recombinant Human Endostatin
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Adenovirus Encoding Recombinant Human Endostatin Definition
A replication-defective, recombinant oncolytic adenovirus encoding human endostatin with potential antineoplastic activity. Endostatin, a 20 kDa C-terminal proteolytic fragment of collagen XVIII, is an important angiogenesis inhibitor. Upon intratumoral administration, the adenovirus infects and replicates in tumor cells. The expressed endostatin may inhibit endothelial cell proliferation and angiogenesis which may result in a reduction of tumor growth.
Adenovirus Encoding Recombinant Human Endostatin Synonyms
Adenovirus Encoding Recombinant Human Endostatin, Ad-rhENDO, E10A
Terms in Adenovirus Encoding Recombinant Human Endostatin category
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