Adrenal Steroid Analogue HE3235
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Adrenal Steroid Analogue HE3235 Definition
An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.
Adrenal Steroid Analogue HE3235 Synonyms
Adrostane Steroid HE3235, 17Alpha-ethynyl-5alpha-androstane-3alpha, 17Beta-diol, APOPTONE, HE3235
Terms in Adrenal Steroid Analogue HE3235 category
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