Cancer Terms

Adrenal Steroid Analogue HE3235

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Therapeutic Hormone -> Therapeutic Steroid Hormone -> Adrenal Agent -> Adrenal Steroid Analogue HE3235

Adrenal Steroid Analogue HE3235 Definition

An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.

Adrenal Steroid Analogue HE3235 Synonyms

Adrostane Steroid HE3235, 17Alpha-ethynyl-5alpha-androstane-3alpha, 17Beta-diol, APOPTONE, HE3235

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