Aldehyde Dehydrogenase-1A2
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Enzyme ->
Oxidoreductase -> Aldehyde Dehydrogenase-1A2
Aldehyde Dehydrogenase-1A2 Definition
Encoded by human ALDH1A2 Gene, Aldehyde Dehydrogenase 1A2 (ADH Family) is a 499-amino acid 54.8 kD putative cytoplasmic homotetrameric NAD-dependent retinaldehyde dehydrogenase, similar to class 1 aldehyde dehydrogenases that synthesizes retinoic acid from retinaldehyde. The protein contains conserved aldehyde dehydrogenase motifs: GXGXXXG motif NAD-binding domain, two peptide motifs, and cys301, critical for aldehyde group interaction. ALDH1A2 and CYP26A1 regulate local retinoic acid levels that act as a signal in developing and adult tissues; CYP26A1 metabolizes retinoic acid. In T-ALL, ectopically expressed TAL1 and LMO in T cells form a complex with GATA3 on the RALDH2-T promoter and activate transcription. (OMIM, Swiss-Prot, and NCI)
Aldehyde Dehydrogenase-1A2 Synonyms
Aldehyde Dehydrogenase 1A2, ALDH1A2, Aldehyde Dehydrogenase 1 Family Member A2, Aldehyde Dehydrogenase 1 Family, Member A2, RALDH(II), RALDH-2, RALDH2, Retinaldehyde-Specific Dehydrogenase Type 2
Terms in Aldehyde Dehydrogenase-1A2 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.