Cancer Terms

Alpha Chemokine

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Cytokine -> Chemokine -> Alpha Chemokine

Alpha Chemokine Definition

Members of the Alpha-Chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also CXC-Chemokines. Some members of the subgroup of the human CXC-Chemokines are defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end. Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils.

Alpha Chemokine Synonyms

Alpha Chemokine, 4q Chemokine, C-X-C Chemokine, CXC Chemokine, Chemokine, CXC

Terms in Alpha Chemokine category

Beta Thromboglobulin
C-X-C Motif Chemokine Ligand-1
Connective-Tissue-Activating Peptide-III
Epithelial Neutrophil Activating Peptide-78
Macrophage Inflammatory Protein-2 Alpha
Macrophage Inflammatory Protein-2 Beta
Neutrophil-Activating Peptide-2
Platelet Basic Protein
Platelet Factor-4
Pro-Platelet Basic Protein
Small Inducible Cytokine-B10
Small Inducible Cytokine-B11
Small Inducible Cytokine-B13
Small Inducible Cytokine-B14
Small Inducible Cytokine-B6
Small Inducible Cytokine-B9
Stromal Cell-Derived Factor-1



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