Alpha-Galactosyl Ceramide-Pulsed Autologous Dendritic Cells

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Alpha-Galactosyl Ceramide-Pulsed Autologous Dendritic Cells Definition

A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T ( NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis.

Alpha-Galactosyl Ceramide-Pulsed Autologous Dendritic Cells Synonyms

Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells, DC-KRN7000, KRN7000-Pulsed Autologous Dendritic Cells

Terms in Alpha-Galactosyl Ceramide-Pulsed Autologous Dendritic Cells category

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