Cancer Terms

Amantadine Hydrochloride

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Anti-Infective Agent -> Antiviral Agent -> Miscellaneous Antiviral Agent -> Amantadine Hydrochloride

Amantadine Hydrochloride Definition

The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

Amantadine Hydrochloride Synonyms

Amantadine Hydrochloride, AMANTADINE HYDROCHLORIDE, Amantadine HCl, Symmetrel

Terms in Amantadine Hydrochloride category



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