Amino-Arginine

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Nitric Oxide Synthetase Inhibitor -> Amino-Arginine

Amino-Arginine Definition

An amino acid derivative. As an analog of arginine, amino-arginine competes with the normal substrate arginine and binds to the heme of the NOS as a false substrate, thereby inhibiting endothelial and inducible nitric oxide synthases (eNOS / NOS III and iNOS / NOS II). Arginine is the only physiological substrate for NOS which, in eukaryotic cells, generates NO and L-citrulline from L-arginine and molecular oxygen in a five-electron transfer reaction. This clinical use of amino-arginine is limited due to its epileptogenic properties. (NCI04)

Amino-Arginine Synonyms

Amino-Arginine

Amino-Arginine

Amino-Arginine Definition

Amino-Arginine Synonyms

Terms in Amino-Arginine category