Cancer Terms

Aminocamptothecin

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor -> Camptothecin Analogue -> Aminocamptothecin

Aminocamptothecin Definition

A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)

Aminocamptothecin Synonyms

Aminocamptothecin, 9-AC, 9-Amino-20-(S)-camptothecin, 9-amino-20(S)-camptothecin, 9-amino-20-camptothecin, 9-amino-CPT, 9-amino-camptothecin, 9-aminocamptothecin, aminocamptothecin

Terms in Aminocamptothecin category



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