Anaplastic Lymphoma Kinase
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Anaplastic Lymphoma Kinase Definition
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene.
Anaplastic Lymphoma Kinase Synonyms
Anaplastic Lymphoma Kinase, ALK, Anaplastic Lymphoma Kinase Ki-1, CD246 Antigen
Terms in Anaplastic Lymphoma Kinase category
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