Anti-CD20 Monoclonal Antibody R7159
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Agent ->
Monoclonal Antibody -> Anti-CD20 Monoclonal Antibody R7159
Anti-CD20 Monoclonal Antibody R7159 Definition
A glycoengineered, fully humanized IgG1 monoclonal antibody with potential antineoplastic activity. Anti-CD20 monoclonal antibody R7159, a third generation type II anti-CD20 antibody, selectivity binds to the extracellular domain of the human CD20 antigen on malignant human B cells. The Fc region carbohydrates of the antibody, enriched in bisected non-fucosylated glycosylation variants, contribute to its higher binding affinity for human FcgammaRIII receptors compared to non-glycoengineered antibodies, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and caspase-independent apoptosis. In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells.
Anti-CD20 Monoclonal Antibody R7159 Synonyms
Anti-CD20 Monoclonal Antibody R7159, GA101, R7159
Terms in Anti-CD20 Monoclonal Antibody R7159 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.