Anti-CTLA4 Human Monoclonal Antibody CP-675 206
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Agent ->
Monoclonal Antibody -> Anti-CTLA4 Human Monoclonal Antibody CP-675 206
Anti-CTLA4 Human Monoclonal Antibody CP-675 206 Definition
A human IgG2a monoclonal antibody directed against the T-cell receptor protein cytotoxic T-lymphocyte-associated protein 4 (CTLA4). Ticilimumab binds to CTLA4 and blocks the binding of the antigen-presenting cell ligands B7-1 and B7-2 to CTLA4, resulting in inhibition of B7-CTLA4-mediated downregulation of T-cell activation; subsequently, B7-1 or B7-2 may interact with another T-cell surface receptor protein, CD28, resulting in a B7-CD28-mediated T-cell activation unopposed by B7-CTLA4-mediated inhibition.
Anti-CTLA4 Human Monoclonal Antibody CP-675 206 Synonyms
Ticilimumab, Anti-CTLA4 Human Monoclonal Antibody CP-675,206, CP-675, CP-675,206, CP-675206
Terms in Anti-CTLA4 Human Monoclonal Antibody CP-675 206 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.