Anti-DLL4 Monoclonal Antibody OMP-21M18
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Anti-DLL4 Monoclonal Antibody OMP-21M18 Definition
A humanized monoclonal antibody directed against the N-terminal epitope of Notch ligand DLL4 (delta-like 4) with potential antineoplastic activity. Anti-DLL4 monoclonal antibody OMP-21M18 binds to the membrane-binding portion of DLL4 and prevents its interaction with Notch-1 and Notch-4 receptors, thereby inhibiting Notch-mediated signaling and gene transcription, which may impede tumor angiogenesis. Activation of Notch receptors by DDL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated into the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development. The expression of DDL4 is highly restricted to the vascular endothelium.
Anti-DLL4 Monoclonal Antibody OMP-21M18 Synonyms
Anti-DLL4 Monoclonal Antibody OMP-21M18, Anti-Delta-like 4 Monoclonal Antibody OMP-21M18, OMP-21M18
Terms in Anti-DLL4 Monoclonal Antibody OMP-21M18 category
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