Anti-EpCAM-Pseudomonas-exotoxin Fusion Protein
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Anti-EpCAM-Pseudomonas-exotoxin Fusion Protein Definition
A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Anti-EpCAM-Pseudomonas-exotoxin fusion protein binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers.
Anti-EpCAM-Pseudomonas-exotoxin Fusion Protein Synonyms
Anti-EpCAM-Pseudomonas-exotoxin Fusion Protein, Proxinium, VB4-845
Terms in Anti-EpCAM-Pseudomonas-exotoxin Fusion Protein category
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