Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Response Modifier -> Immunoconjugate -> Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547

Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547 Definition

An auristatin analogue immunoconjugate directed against Eph receptor A2 (EphA2)-positive cancer cells with potential antineoplastic activity. Anti-EphA2 monoclonal antibody-MMAF immunoconjugate MEDI-547 is generated by conjugating the fully human IgG1 anti-EphA2 monoclonal antibody (1C1) to the small-molecule microtubule inhibitor monomethyl auristatin phenylalanine (MMAF) via the stable linker maleimidocaproyl (mc) (1C1-mcMMAF). The monoclonal antibody moiety of this agent selectively binds to cells expressing the EphA2 receptor. After internalization and enzymatic cleavage of the immunoconjugate within the tumor cell cytosol, free MMAF binds to tubulin and inhibits its polymerization, which may result in G2/M phase arrest and tumor cell apoptosis. The cell-surface receptor EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed by a variety of different cancer cell types.

Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547 Synonyms

Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547, 1C1-mcMMAF, Medi-547

Terms in Anti-EphA2 Monoclonal Antibody-MMAF Immunoconjugate MEDI-547 category

---

Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.