Anti-ErbB3 Receptor Monoclonal Antibody MM-121
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Biological Agent ->
Monoclonal Antibody -> Anti-ErbB3 Receptor Monoclonal Antibody MM-121
Anti-ErbB3 Receptor Monoclonal Antibody MM-121 Definition
A fully human monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (Her3) with potential antineoplastic activity. Anti-ErbB3 receptor monoclonal antibody MM-121 binds to and inhibits ErbB3 activation, which may result in inhibition of ErbB3-dependent PI3K/Akt signaling and so inhibition of cellular proliferation and differentiation. ErbB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in solid tumors, including breast, lung, and colorectal tumors of epithelial origin; it has no active kinase domain itself but is activated through heterodimerization with other members of the EGFR receptor family that do.
Anti-ErbB3 Receptor Monoclonal Antibody MM-121 Synonyms
Anti-ErbB3 Receptor Monoclonal Antibody MM-121, MM-121
Terms in Anti-ErbB3 Receptor Monoclonal Antibody MM-121 category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.