Anti-IGF-1R Human Monoclonal Antibody R1507
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Anti-IGF-1R Human Monoclonal Antibody R1507 Definition
A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Anti-IGF-1R human monoclonal antibody R1507 binds to membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the activation of PI3K/AKT signal transduction; downregulation of the PI3K/AKT survival pathway may result in the induction of apoptosis and decreased cellular proliferation. The activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.
Anti-IGF-1R Human Monoclonal Antibody R1507 Synonyms
Anti-IGF-1R Human Monoclonal Antibody R1507, R1507
Terms in Anti-IGF-1R Human Monoclonal Antibody R1507 category
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