Natural or synthetic Anti-lipidemic Agents reduce plasma lipids, such as cholesterol or low density lipoproteins (LDL), acting systemically or locally (intestines) to decrease fat digestion, absorption, production, and accumulation in the plasma and reducing pathogenic atherosclerosis and thrombosis. Cholestyramine, fibrates, nicotinic acid and HMG-CoA reductase inhibitors are examples of anti-lipidemic agents. (NCI04)