Antithymocyte Globulin
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Antithymocyte Globulin Definition
A purified gamma immunoglobulin (IgG) with immunosuppressive activity. Obtained from rabbits that have been immunized with human thymocytes, antithymocyte globulin specifically recognizes and destroys T lymphocytes. Although the exact mechanism of action is not completely understood, it appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering antithymocyte globulin with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host disease.
Antithymocyte Globulin Synonyms
Anti-Thymocyte Globulin, ATG, ATGAM, ATS, Antithymocyte Globulin, Antithymocyte Serum, Thymoglobulin, antithymocyte globulin
Terms in Antithymocyte Globulin category
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