Aromatase Cytochrome-P450
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Aromatase Cytochrome-P450 Definition
Aromatase is a unique member of the cytochrome P450 enzyme superfamily that catalyzes formation of aromatic C18 estrogens from C19 androgens by desaturating ring A of the steroid. One of two components of the aromatase enzyme complex, aromatase is present in many tissues including skin, muscle, fat, and nerve, where it may contribute to sex-specific differences in cellular metabolism. The other component of aromatase is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to P450(arom). Class I cytokines such as IL6 and IL11, as well as TNF-alpha, are important regulatory factors of the CYP19 (aromatase) gene. (from OMIM 107910 and NCI)
Aromatase Cytochrome-P450 Synonyms
Aromatase Cytochrome P450, Aromatase, CYP19, CYP19A1, CYPXIX, Cytochrome P450 19A1, Cytochrome P450, Family 19, Subfamily A, Polypeptide 1, Cytochrome P450, Subfamily XIX, Cytochrome P450, Subfamily XIX (Aromatization of Androgens), EC 1.14.14.1, Estrogen Synthetase, Flavoprotein-Linked Monooxygenase, Microsomal Monooxygenase, p450arom
Terms in Aromatase Cytochrome-P450 category
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