Aspartate Carbamoyltransferase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Aspartate Carbamoyltransferase

Aspartate Carbamoyltransferase Definition

Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade.