Cancer Terms

Aurora A Kinase Inhibitor MLN8237

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Serine Threonine Kinase Inhibitor -> Aurora Kinase Inhibitor -> Aurora A Kinase Inhibitor MLN8237

Aurora A Kinase Inhibitor MLN8237 Definition

A second-generation, orally available, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.

Aurora A Kinase Inhibitor MLN8237 Synonyms

Aurora A Kinase Inhibitor MLN8237, MLN8237

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