B-Cell Linker

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> B-Cell Linker

B-Cell Linker Definition

B-Cell Linker, encoded by the BLNK gene, is essential for normal B-cell development. This protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins. Tyrosine phosphorylation of B-Cell Linker by SYK provides docking sites for these SH2-containing effector molecules that, in turn permits the phosphorylation and/or activation of their respective signaling pathways. Thus, B-Cell Linker represents a central linker protein that bridges the B-cell receptor-associated kinases with a multitude of signaling pathways and may regulate biologic outcomes of B-cell function and development. The somatic loss of the BLNK gene and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL. (From OMIM and NCI)

B-Cell Linker Synonyms

B-Cell Linker, B Cell Linker Protein, B-Cell Linker Protein, BLNK

B-Cell Linker

B-Cell Linker Definition

B-Cell Linker Synonyms

Terms in B-Cell Linker category