BAG1 Protein
Cancer Terms ->
Gene Product ->
Protein ->
Protein Organized by Function ->
Signaling Protein -> BAG1 Protein
BAG1 Protein Definition
Encoded by human BAG1 Gene as isoforms 1 (274-aa, 31-kD) and 2 (240-aa), acidic (pI 5.3) glutamate-rich BAG1 Protein contains a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death.
BAG1 Protein Synonyms
BAG1 Protein, BAG1, BCL2-associated Athanogene
Terms in BAG1 Protein category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.