BCL2-Associated Athanogene-4
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BCL2-Associated Athanogene-4 Definition
This protein is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. (LocusLink)
BCL2-Associated Athanogene-4 Synonyms
BCL2-associated Athanogene 4, BAG-Family Molecular Chaperone Regulator-4, BAG4
Terms in BCL2-Associated Athanogene-4 category
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