BIR Domain

Cancer Terms -> Anatomic Structure System or Substance -> Microanatomy -> Macromolecular Structure -> Protein Structure -> Protein Domain -> Ligand Binding Domain -> Protein Binding Domain -> BIR Domain

BIR Domain Definition

Containing perfectly conserved histidine and cysteines residues. the BIR domain is about 70 residues long arranged in tandem repeats separated by a linker of variable length. Found in IAP (Inhibitor of Apoptosis Protein) Family proteins, it seems to confer cell death-preventing activity. Except NAIP, family members typically contain two or three BIR repeats and a C-terminal RING finger. A second group of BIR-domain-containing proteins (BIRPs) include mammalian Bruce and Survivin proteins, as well as BIR-containing proteins in yeasts and C. elegans. Survivin-like BIRPs regulate cytokinesis and mitotic spindle formation. (NCI)

BIR Domain Synonyms

BIR Domain, BIR Motif, Baculovirus Inhibitor of Apoptosis Protein Repeat, IAP Repeat, Inhibitor of Apoptosis Domain

BIR Domain

BIR Domain Definition

BIR Domain Synonyms

Terms in BIR Domain category