BRCA1 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> BRCA1 Protein

BRCA1 Protein Definition

BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression. BRCA1 participates in transcription-coupled repair of oxidative DNA damage. (LocusLink)

BRCA1 Protein Synonyms

BRCA1 Protein, BRCA1, Breast Cancer 1, Early Onset Protein, Breast Cancer Type 1 Susceptibility Protein, Breast-Ovarian Cancer Protein

BRCA1 Protein

BRCA1 Protein Definition

BRCA1 Protein Synonyms

Terms in BRCA1 Protein category