BUB1 Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> BUB1 Protein

BUB1 Protein Definition

BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast), encoded by the human BUB1 gene, is a 120-kD serine/threonine protein kinase. This protein monitors the attachment of chromosomes to spindle poles and may be a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. As part of a common complex in checkpoint-activated cells, Bub1 monitors different spindle events compared to BubR1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. It interacts with Bub3, CENP-F, CENP-E and mitosin. The BUB1 gene is highly expressed in thymus followed by spleen. Defects in Bub1 are associated with tumor formation. (From LocusLink, Swiss_Prot and NCI)

BUB1 Protein Synonyms

BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog, BUB1, BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast)

BUB1 Protein

BUB1 Protein Definition

BUB1 Protein Synonyms

Terms in BUB1 Protein category