Cancer Terms

Base Excision Repair

Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> DNA Maintenance Process -> DNA Maintenance -> DNA Repair -> Excision Repair -> Base Excision Repair

Base Excision Repair Definition

Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.

Base Excision Repair Synonyms

Base Excision Repair, DNA Base Excision Repair

Terms in Base Excision Repair category



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