Base Pair Miscoding
Cancer Terms -> Biological Process -> Subcellular Process -> Biochemical Process -> Molecular Sequence Alteration -> DNA Sequence Alteration -> Mutation -> Base Pair Miscoding
Base Pair Miscoding Definition
Base Pair Miscoding involves flawed activity of biologic molecules or complexes that incorporate incorrect non-complementary paired nucleotides (base pairs) between the linear polymeric antiparallel double helical DNA strands during replication (typically), repair, or rearrangement. The antiparallel double helical strands contain phosphate-linked deoxyribose units in N-glycosidic linkage with heterocyclic nitrogenous pyrimidine (cytosine, thymine) or purine (adenine, guanine) bases lying internal and perpendicular to the axis; complementary adenine-thymine or cytosine-guanine base pairs on the adjacent strands hydrogen bond. In a transition point mutation, a purine base replaces a purine base, or a pyrimidine base replaces a pyrimidine base. In a transversion point mutation a purine base replaces a pyrimidine base, or vice versa.Base Pair Miscoding Synonyms
Base Pair MiscodingTerms in Base Pair Miscoding category
Transition MutationTransversion Mutation