Bloom Syndrome Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Helicase -> DNA Helicase -> RecQ Helicase Family Protein -> Bloom Syndrome Protein

Bloom Syndrome Protein Definition

BLM protein is a glycopeptide of 417 amino acids within which ATP binding domain is in amino acid 689-696, DEAH box in 795-798, and 2 putative nuclear localization signals in the C-term in 1334-1349. It is expressed at high level in S phase, and persists in G2/M and sharply declines in G1. It function as a 3'-5'DNA helicase, and probably plays a role in DNA replication and repair. It participates in a supercomplex of BRCA1 -associated proteins named BASC (BRCA1-Associated genome Surveillance Complex).

Bloom Syndrome Protein Synonyms

Bloom Syndrome Protein, BLM, BLM Protein, DNA Helicase, RECQ-Like, Type 2

Bloom Syndrome Protein

Bloom Syndrome Protein Definition

Bloom Syndrome Protein Synonyms

Terms in Bloom Syndrome Protein category