Bone Morphogenetic Protein Receptor Type-IA

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Receptor Serine-Threonine Kinase -> Bone Morphogenetic Protein Receptor Type-IA

Bone Morphogenetic Protein Receptor Type-IA Definition

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Germline mutations in BMPR1A cause a subset of juvenile polyposis syndrome and Cowden syndrome. (From LocusLink)

Bone Morphogenetic Protein Receptor Type-IA Synonyms

Bone Morphogenetic Protein Receptor, Type IA, BMPR1A

Terms in Bone Morphogenetic Protein Receptor Type-IA category

---

Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.