Bone Morphogenetic Protein Receptor Type-II
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Bone Morphogenetic Protein Receptor Type-II Definition
Encoded by human BMPR2 Gene (BMP Receptor Family), Bone Morphogenetic Protein Receptor Type II is a type II transmembrane serine/threonine kinase receptor for BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. BMP receptors transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling; type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. (NCI)
Bone Morphogenetic Protein Receptor Type-II Synonyms
Bone Morphogenetic Protein Receptor Type II, BMPR2, Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase)
Terms in Bone Morphogenetic Protein Receptor Type-II category
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