Brain-Derived Neurotrophic Factor
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Brain-Derived Neurotrophic Factor Definition
Brain-Derived Neurotrophic Factor is a member of the nerve growth factor family. It exerts trophic action on retinal, cholinergic, and dopaminergic neurons in the brain and on motor and sensory neurons in the peripheral nervous system. Target cells regulate neuronal survival by producing neurotrophic factors, such as NGF and BDNF, which show sequence similarity. Proforms of NGF and BDNF are secreted and cleaved by plasmin serine protease and matrix metalloproteinases (MMP7, MMP3); proforms preferentially activate p75(NTR) to mediate apoptosis and mature forms activate TRK receptors to promote survival. Huntingtin up regulates transcription of BDNF. Mutated Huntingtin decreases production of BDNF leading to neuronal death. (from OMIM 113505 and NCI)
Brain-Derived Neurotrophic Factor Synonyms
Brain-Derived Neurotrophic Factor, BDNF, MGC34632
Terms in Brain-Derived Neurotrophic Factor category
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